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長庚大學臨床資訊與醫學統計研究中心

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劉碧華 助理教授

1.姓名:劉碧華
2.工作單位:長庚大學
3.職稱:助理教授
4.科別:臨床資訊與醫學統計研究中心
5.辦公室地址:333桃園市龜山區文化一路259號第二醫學大樓5樓
6.辦公室電話/傳真: (03) 211-8800 #3758 / (03)-2118453
7.電子信箱:phliu@mail.cgu.edu.tw
8.個人網站: http://cims.cgu.edu.tw/files/11-1079-4463.php

9.研究領域:
內分泌與代謝
基因流行病學
醫學統計
公共衛生及環境醫學

10.工作經歷:
臺灣大學公共衛生學院專案助理教授

11.學歷:
臺灣大學公共衛生學院流行病學與預防醫學研究所博士

12.殊榮(獲獎消息):無

13.代表論文(至多5篇、不用附IF值):
(1) Lin YS†, Liu PH†, Lin SW, Chuang LP, Ho WJ, Chou YT, Juan KC, Lo MT, Chu PH, Chen NH*. Simple obstructive sleep apnea patients without hypertension or diabetes accelerate kidney dysfunction: A population follow-up cohort study from Taiwan. Sleep Breath. 2017;21(1):85-91. († equal contribution)

(2) Yu HH, Liu PH, Yang YH, Lee JH, Wang LC, Chen WJ, Chiang BL*. Chemokine MCP1/CCL2 and RANTES/CCL5 gene polymorphisms influence HenocheSchonlein purpura susceptibility and severity. J Formos Med Assoc. 2015;114(4):347-352.

(3) Chang YC†, Liu PH†, Yu YH, Kuo SS, Chang TJ, Jiang YD, Nong JY, Hwang JJ, Chuang LM*. Validation of type 2 diabetes risk variants identified by genome-wide association studies in han chinese population: a replication study and meta-analysis. PloS one. 2014;9(4):e95045. († equal contribution)

(4) Huang TP†, Liu PH†, Lien SY, Yang SL, Chang HH, Yen HR*. Characteristics of traditional Chinese medicine use in children with asthma: a nationwide population-based study. Allergy. 2013;68(12):1610-1613. († equal contribution)

(5) Chang YC†, Liu PH†, Tsai YC, Chiu YF, Ho L, Lee WJ, Lu CH, Quertermos T, Curb JD, Lee WJ, Lee PC, He YH, Yeh JI, Hwang JJ, Tsai SH, Chuang LM*. Genetic Variation in the Carbonyl Reductase 3 Gene Confers Risk of Type 2 Diabetes and Insulin Resistance: Potential Regulator of Adipogenesis. J Mol Med. 2012;90:847-59. († equal contribution)

14.專利:

15.學會或專業認證:台灣公共衛生學會、中華民國糖尿病學會

16.目前進行中研究計畫的計劃名(起、迄日期):

17.五年內發表期刊論文:(† 共同第一作者; * 通訊作者)
(1) Lin YS, Liu PH, and Chu PH*. Obstructive Sleep Apnea Independently Increases the Incidence of Heart Failure and Major Adverse Cardiac Events: A Retrospective Population-Based Follow-Up Study. Acta Cardiol Sin. 2017;33(6): 656–663.

(2) Lin YS, Liu PH, Chen NH. Reply to "Obstructive sleep apnea patients without hypertension or diabetes and subsequent incidence of chronic kidney disease" by Kawada (letter to the editor). Sleep Breath. 2017, https://doi.org/10.1007/s11325-017-1585-3

(3) Lin YS†, Liu PH†, Lin SW, Chuang LP, Ho WJ, Chou YT, Juan KC, Lo MT, Chu PH, Chen NH*. Simple obstructive sleep apnea patients without hypertension or diabetes accelerate kidney dysfunction: A population follow-up cohort study from Taiwan. Sleep Breath. 2017;21(1):85-91. († equal contribution)

(4) Yu HH, Liu PH, Yang YH, Lee JH, Wang LC, Chen WJ, Chiang BL*. Chemokine MCP1/CCL2 and RANTES/CCL5 gene polymorphisms influence HenocheSchonlein purpura susceptibility and severity. J Formos Med Assoc. 2015;114(4):347-352.

(5) Hung CS, Li HY, Kuo CH, Lin MS, Kuo TC, Tsai SJ, Liu PH, Lin CH, Yang CY, Chuang LM, Chen MF, Tseng YJ, and Kao HL*. Fasting but not changes of plasma metabolome during oral glucose tolerance tests improve the diagnosis of severe coronary arterial stenosis. Clin Endocrinol. 2015;83(4):483-489.

(6) Hung CS, Lee JK, Yang CY, Hsieh HR, Ma WY, Lin MS, Liu PH, Shih SR, Liou JM, Chuang LM, Chen MF, Lin JW, Wei JN, Li HY*. Measurement of visceral fat: should we include retroperitoneal fat? PLoS One. 2014;9(11):e112355.

(7) Ma WY, Yu TY, Wei JN, Hung CS, Lin MS, Liao YJ, Pei D, Su CC, Lu KC, Liu PH, Lin CH, Chuang LM, Kao HL, Lin JW, Chuang YJ, Li HY*. Plasma apelin: a novel biomarker for predicting diabetes. Clin Chim Acta. 2014;435:18-23.

(8) Huang TP†, Liu PH†, Lien AS, Yang SL, Chang HH, Yen HR*. A nationwide population-based study of traditional Chinese medicine usage in children in Taiwan. Complement Ther Med. 2014;22(3):500-510. († equal contribution)

(9) Chang YC†, Liu PH†, Yu YH, Kuo SS, Chang TJ, Jiang YD, Nong JY, Hwang JJ, Chuang LM*. Validation of type 2 diabetes risk variants identified by genome-wide association studies in han chinese population: a replication study and meta-analysis. PloS one. 2014;9(4):e95045. († equal contribution)

(10) Yu CH†, Liu PH†, Van YH, Lien AS, Huang TP, Yen HR*. Traditional Chinese medicine for idiopathic precocious puberty: A hospital-based retrospective observational study. Complement Ther Med. 2014;22(2):258-265. († equal contribution)

(11) Lin YS, Liu PH, Wu LS, Chen YM, Chang CJ, Chu PH*. Major adverse cardiovascular events in adult congenital heart disease: a populationbased follow-up study from Taiwan. BMC Cardiovasc Disord. 2014;14:38.

(12) Lin JF†, Liu PH†, Huang TP, Lien AS, Ou LS, Yu CH, Yang SL, Chang HH, Yen HR*. Characteristics and prescription patterns of traditional Chinese medicine in atopic dermatitis patients: ten-year experiences at a medical center in Taiwan. Complement Ther Med. 2014;22(1):141-147. († equal contribution)

(13) Wu LS†, Liu PH†, Lin YS, C. Lin CP, Chang CJ*, Chu PH*. Lupus women with delivery with higher risk of heart failure, compared with those without pregnancy but neutral in major adverse cardiovascular events. A population-based matched cohort study. Clin Exp Rheumatol. 2014;32(1):108-112. († equal contribution)

(14) Huang TP†, Liu PH†, Lien SY, Yang SL, Chang HH, Yen HR*. Characteristics of traditional Chinese medicine use in children with asthma: a nationwide population-based study. Allergy. 2013;68(12):1610-1613. († equal contribution)

(15) Chang YC, Chiu YF, Liu PH, Hee SW, Chang TJ, Jiang YD, Lee WJ, Lee PC, Kao HY, Hwang JJ, Chuang LM*. Genetic variation in the NOC gene is associated with body mass index in Chinese subjects. PLoS One. 2013;8:e69622.

(16) Ma WY, Yang CY, Shih SR, Hsieh HJ, Hung CS, Chiu FC, Lin MS, Liu PH, Hua CH, Hsein YC, Chuang LM, Lin JW, Wei JN, Li HY*. Measurement of Waist Circumference - Midabdominaln or Iliac Crest? Diabetes Care. 2013;36(6):1660-1666.

(17) Wang SH, Chen WJ, Chuang LM, Hsiao PC, Liu PH, Hsiao CK*. Inference of cross-level interaction between genes and contextual factors in a matched case-control metabolic syndrome study: a Bayesian approach. PLoS One. 2013;8: e56693.

(18) Chien KL, Hsu HC, Liu PH, Lin HJ, Chen MF*. Common sequence variants in CD36 gene and the levels of triglyceride and high-density lipoprotein cholesterol among ethnic Chinese in Taiwan. Lipids Health Dis. 2012;11:174.

(19) Chang YC†, Liu PH†, Tsai YC, Chiu YF, Ho L, Lee WJ, Lu CH, Quertermos T, Curb JD, Lee WJ, Lee PC, He YH, Yeh JI, Hwang JJ, Tsai SH, Chuang LM*. Genetic Variation in the Carbonyl Reductase 3 Gene Confers Risk of Type 2 Diabetes and Insulin Resistance: Potential Regulator of Adipogenesis. J Mol Med. 2012;90:847-59. († equal contribution)

(20) Cheng JS, Wu BS, Wen YW, Liu PH, Lin JR, Chang CJ*. Biosignatures: Comparative effectiveness research in biomarker clinical studies. J Formos Med Assoc. 2012;111:300-304.

(21) Chang YC, Chiu YF, Liu PH, Shih KC, Lin MW, Sheu Wayne HH, Quertermous T, Curb JD, Hsiung CA, Lee WJ, Lee PC, Chen YT, Chuang LM. Replication of genome-wide association signals of type 2 diabetes in Han Chinese in a prospective cohort. Clin Endocrinol. 2012;76:365–372.

(22) Chang TJ, Liu PH, Liang YC, Chang YC, Jiang YD, Li HY, Lo MT, Chen HS, Chuang LM*. Genetic predisposition and nongenetic risk factors of thiazolidinedione-related edema in subjects with type 2 diabetes. Pharmacogenet Genom. 2011;21:829-836.

(23) Wang SH, Hsiao PC, Hsiao CK, Liu PH, Chien KL, Lin SR, Lee WC, Chen WJ*. Multilevel analysis of habitual physical activity and metabolic syndrome in northern Taiwan. Prev Med. 2011;53: 34-38.

(24) Chien KL, Chao CL, Kuo CH, Lin HJ, Liu PH, Chen PR, Hsu HC, Lee BC, Lee YT, Chen MF*. Plasma fatty acids and the risk of metabolic syndrome in ethnic Chinese adults in Taiwan. Lipids Health Dis. 2011;10:33.

(25) Yu HH, Liu PH, Lin YC, Chen WJ, Lee JH, Wang LC, Yang YH, Chiang BL*. Interleukin-4 and STAT6 Gene Polymorphisms are Associated with Systemic Lupus Erythematosus in Chinese Patients. Lupus. 2010;19:1219-1228.

(26) Liu PH†, Chang YC†, Jiang YD, Chen WJ, Chang TJ, Kuo SS, Lee KC, Hsiao PC, Chiu KC, Chuang LM. Genetic Variants of TCF7L2 are Associated with Insulin Resistance and Related Metabolic Phenotypes in Taiwanese Adolescents and Caucasian Young Adults. J Clin Endocr Metab. 2009;94: 3575-3582. († equal contribution)

(27) Liu PH†, Jiang YD†, Chen WJ†, Chang CC, Lee TC, Sun H.S, Chuang LM. Genetic and environmental influences on adiponectin, leptin, and BMI among adolescents in Taiwan: a multivariate twin/sibling analysis. Twin Res Hum Genet. 2008;11:495-504. († equal contribution)

(28) Chang YC, Liu PH, Lee WJ, Chang TJ, Jiang YD, Li HY, Kuo SS, Lee KC, Chuang LM*. Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population. Diabetes. 2008;57: 2245-2252.

(29) Kuo SY, Liu PH, Chuang LM, Chen WJ*. The Taipei Adolescent Twin/Sibling Family Study II: Depression, insulin resistance, and hormonal factors. Twin Res Hum Genet. 2006;9:895-98.

(30) Wu SJ, Chiang FT, Chen WJ, Liu PH, Hsu KL, Hwang JJ, Lai LP, Lin JL, Tseng CD, Tseng YZ. Three single-nucleotide polymorphisms of the angiotensinogen gene and susceptibility to hypertension: single locus genotype vs. haplotype analysis. Physiol Genomics. 2004;17:79-86.

(31) Chen WJ*, Liu PH, Ho YY, Chien KL, Lo MT, Shih WL, Yen YC, Lee WC. Sibling recurrence risk ratio analysis of the metabolic syndrome and its components over time. BMC Genet. 2003;4(Suppl 1):S33.
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