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Jr-Rung Lin

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1.Name:Jr-Rung Lin
2.Institution:Chang Gung University
3.Position:Associate Professor

4.Department:
Clinical Informatics and Medical Statistics Research Center (CIMS),
Graduate Institute of Clinical Medical Sciences,
Department of Biomedical Sciences;
Department of Anesthesiology, Chang Gung Memorial Hospital

5.Address:No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 33302, Taiwan
6.Tel(GSM optional)/Fax:+886-3-2118800 ext.3756
7.E-mail:jr@mail.cgu.edu.tw
8.Personal Website:http://cims.cgu.edu.tw/files/15-1079-17012,c4463-1.php
9.Focus of Interest:
Statistical methodology in clinical trials
Statistical design in clinical research and development
Statistical Inference in targeted clinical trials
Experimental epidemiology research and design
Assay validation in pharmaceutical development

10.Fulltime Employment:
Associate Professor, Clinical Informatics and Medical Statistics Research Center,
and Graduate Institute of Clinical Medical Sciences (Joint Appointment), Chang Gung University, 2017/08–Present
Associate Professor, Department of Biomedical Sciences (Joint Appointment), Chang Gung University, 2018/02–Present
Joint Appointment Associate Research Fellow, Department of Anesthesiology, Chang Gung Memorial Hospital, 2017/08–Present
Joint Appointment Assistant Research Fellow, Department of Anesthesiology, Chang Gung Memorial Hospital, 2016–2017/07
Assistant Professor, Clinical Informatics and Medical Statistics Research Center,
and Graduate Institute of Clinical Medical Sciences (Joint Appointment), Chang Gung University, 2009–2017/07
Statistical Consultant, Resource Center for Clinical Research, Chang Gung Memorial Hospital, 2009–2016
Postdoctor Fellow, Statistics Education Center, National Taiwan University, 02/2009–07/2009
Visiting Graduate Student (Graduate Students Research Abroad Program of NSC),
Department of Biostatistics and Bioinformatics, Duke University School of Medicine, USA, 05/2007–01/2008
Adjunct Instructor, National Taipei College of Nursing, 08/2004–01/2009
Biostatistician, Clinical Research Lab/Division of Biostatistics, Koo Foundation Sun Yet-Sen Cancer Center, 06/2002–05/2003
Adjunct Instructor, Department of Information Management, Shih Hsin University, 08/2001–07/2002
Assistant Researcher, Institute of Public Opinion, Shih Hsin University, 11/2000–05/2002
Research Staff, Secretary Office, Taipei Wanfang Hospital, 01/2000–10/

11.Education:
Ph.D. in Biostatistics, National Taiwan University

12.Honors and Awards:

13.SelectedMain Publications(up to 5 ):
1.Tsai Y.F., Chen H.P., Liu F.C., Liu S.H., Chen C.Y., Cheng C.W., and Lin J.R.**, "Nationwide Population-based Study Reveals Increased Malignancy Risk in Taiwanese Liver Transplant Recipients", Oncotarget. (Dec, 2016), 7(50):83784-83794. (SCI, Impact Factor: 5.008, Rank: 36/213)

2.Hong C.H., Tu H.P., Lin J.R., and Lee C.H., "An estimation of the incidence of tuberous sclerosis complex in a nationwide retrospective cohort study (1997–2010)", British Journal of Dermatology. (Jun, 2016), 174(6): 1282-9. (SCI, Impact Factor: 4.317, Rank: 5/61)

3.Liu C.H.*, Lin S.C.*, Lin J.R., Yang J.T., Chang Y.J., Chang C.H., Chang T.Y., Huang K.L., Ryu S.J., and Lee T.H., " Dehydration is an independent predictor of discharge outcome and admission cost in acute ischaemic stroke", European Journal of Neurology. (Sep, 2014), 21(9): 1184-91. (SCI, Impact Factor: 3.956, Rank: 38/193)

4.Lin J.R., Chow S.C., Chang C.H., Lin Y.C., and Liu J.P., ''Application of the parallel line assay to assessment of biosimilar products based on binary endpoints'', Statistics in Medicine. (Dec, 2013), 32(3): 449-461. (SCI, Impact Factor: 1.533, Rank: 31/123)

5.Hsu K.Y., Lin J.R.**, Lin M.S., Chen W., Chen Y.J., and Yan Y.H., ''The modified medical research council (mMRC) dyspnoea scale is a good indicator of health-related quality of life in patients with COPD'', Singapore Medical Journal. (Jun, 2013), 54(6): 321-327. (SCI, Impact Factor: 0.573, Rank: 118/155)

* Equal Contributions
** Corresponding Author

14.Patents:

15.Board Certification / Professional Affiliations:

16.Ongoing projects:

17.All publications:
1. Lee J.T., Kuo H.Y., Huang K.G., Lin J.R., Chen M.L. (2020) ''Diversity of sexual activity and correlates among women with gynecological cancer '', Gynecol Oncol. S0090-8258(20)33761-6. doi: 10.1016/j.ygyno.2020.08.005.

2. ]Lee T.H., Yang J.T., Lin J.R., Hu C.J., Chou W.H., Lin C.P., Chi N.F. (2020) ''Protective effects of ischemic preconditioning against neuronal apoptosis and dendritic injury in the hippocampus are age-dependent'', J Neurochem. doi: 10.1111/jnc.15029.

3. Lin H.C., Lin J.R., Tsai W.C., Lu C.H., Chang W.N., Huang C.C., Wang H.C., Kung C.T., Su C.M., Su Y.J., Lin W.C., Cheng B.C., Hsu C.W., Lai Y.R., Tsai N.W. (2019) ''The outcomes of statin therapy in patients with acute ischemic stroke in Taiwan: a nationwide epidemiologic study'', QJM. 112(12):891-899. doi: 10.1093/qjmed/hcz189.

4. Hsieh C.H., Lin C.Y., Hsu C.L., Fan K.H., Huang S.F., Liao C.T., Lee L.Y., Ng S.K., Yen T.C., Chang J.T., Lin J.R., Wang H.M. (2019) ''Incorporation of Astragalus polysaccharides injection during concurrent chemoradiotherapy in advanced pharyngeal or laryngeal squamous cell carcinoma: preliminary experience of a phase II double-blind, randomized trial'', J Cancer Res Clin Oncol. 146(1):33-41. doi: 10.1007/s00432-019-03033-8.

5. Huang Y.H., Chen S.T., Liu F.H., Hsieh S.H., Lin C.H., Liou M.J., Wang C.C., Huang C.H., Liu G.H., Lin J.R., Yang L.Y., Hsu T.Y., Lee M.C., Huang C.T., Wu Y.H. (2019) ''The efficacy and safety of concentrated herbal extract granules, YH1, as an add-on medication in poorly controlled type 2 diabetes: A randomized, double-blind, placebo-controlled pilot trial'', PLoS ONE. 14(8):e0221199. doi: 10.1371/journal.pone.0221199.

6. Lin H.C., Tsai W.C., Lin J.R., Chang W.N., Huang C.C., Wang H.C., Kung C.T., Su C.M., Su Y.J., Lin W.C., Cheng B.C., Lu C.H., Tsai N.W. (2019) ''Adjunctive statin therapy reduces intracranial hemorrhage and 1-year mortality in patients with atrial fibrillation after acute ischemic stroke: A population-based epidemiological study from Taiwan'', J Clin Neurosci. 69:224-229. doi: 10.1016/j.jocn.2019.07.045.

7. Chang F.C., Lin J.R., Liu F.C. (2019) ''Validity of accuracy and trending ability of non-invasive continuous total hemoglobin measurement in complex spine surgery: a prospective cohort study'', BMC Anesthesiol. 19(1):117. doi: 10.1186/s12871-019-0790-y.

8. Chiang S.F., Chen J.S., Tang R., Yeh C.Y., Hsieh P.S., Tsai W.S., You J.F., Hung H.Y., Lai C.C., Lin J.R., Chiang J.M. (2019) ''The impact of kidney function on colorectal cancer patients with localized and regional diseases: An observational study from Taiwan'', Indian J Cancer. 56(3):241-247. doi: 10.4103/ijc.IJC_294_18.

9. Lin H.T., Cheng M.L., Lo C.J., Lin G., Lin S.F., Yeh J.T., Ho H.Y., Lin J.R., Liu F.C. (2019) ''1H Nuclear Magnetic Resonance (NMR)-Based Cerebrospinal Fluid and Plasma Metabolomic Analysis in Type 2 Diabetic Patients and Risk Prediction for Diabetic Microangiopathy'', J Clin Med. 8(6):874. doi: 10.3390/jcm8060874.

10. Wang S.Y., Lin K.J., Chen S.W., Cheng C.T., Chang C.H., Wu Y.T., Liao C.A., Liao C.H., Fu C.Y., Lin J.R., Hsieh C.H. (2019) ''Long-term renal outcomes in patients with traumatic renal injury after nephrectomy: A nationwide cohort study'', Int J Surg. 65:140-146. doi: 10.1016/j.ijsu.2019.04.001.

11. Lin Y.C., Cho A.H., Lin J.R., Chung Y.T. (2019) ''The Clarus Video System (Trachway) and direct laryngoscope for endotracheal intubation with cricoid pressure in simulated rapid sequence induction intubation: a prospective randomized controlled trial'', BMC Anesthesiol. 19(1):33. doi: 10.1186/s12871-019-0703-0.

12. Peng Y.S., Lin J.R., Cheng B.H., Ho C., Lin Y.H., Shen C.H., Tsai M.H. (2019) ''Incidence and relative risk for developing cancers in women with gestational diabetes mellitus: a nationwide cohort study in Taiwan'', BMJ Open. 9(2):e024583. doi: 10.1136/bmjopen-2018-024583.

13. Liu F.C., Shen S.J., Lin J.R., Yu H.P. (2019) ''Investigation of prostate resected weight on postoperative sexual dysfunction following transurethral resection of prostate surgery: a population-based study'', Ther Clin Risk Manag. 15:113-118. doi: 10.2147/TCRM.S186822.

14. Liu F.C., Hua K.C., Lin J.R., Pang S.T., Yu H.P. (2019) ''Prostate resected weight and postoperative prostate cancer incidence after transurethral resection of the prostate: A population-based study'', Medicine (Baltimore). 98(3):e13897. doi: 10.1097/MD.0000000000013897.

15. Tsai H.I., Lo C.J., Zheng C.W., Lee C.W., Lee W.C., Lin J.R., Shiao M.S., Cheng M.L., Yu H.P. (2018) ''A Lipidomics Study Reveals Lipid Signatures Associated with Early Allograft Dysfunction in Living Donor Liver Transplantation'', J Clin Med. 8(1):30. doi: 10.3390/jcm8010030.

16. Yang S.H., Lin Y.H., Lin J.R., Chen H.Y., Hu S., Yang Y.H., Yang Y.H., Yang Y.S., Fang Y.F. (2018) ''The Efficacy and Safety of a Fixed Combination of Chinese Herbal Medicine in Chronic Urticaria: A Randomized, Double-Blind, Placebo-Controlled Pilot Study'', Front Pharmacol. 9:1474. doi: 10.3389/fphar.2018.01474.

17. Lai Y.R., Lin J.R., Chang W.N., Tsai N.W., Huang C.C., Wang H.C., Su Y.J., Lin W.C., Cheng B.C., Su C.M., Hsiao S.Y., Kuo C.E., Lu C.H. (2019) ''Outcomes of adjunctive steroid therapy in adult patients with bacterial meningitis in Taiwan: A nationwide population-based epidemiologic study'', J Clin Neurosci. 1 61:54-58. doi: 10.1016/j.jocn.2018.10.146.

18. Hsiao YJ, Liu FC, Chen HP, Tsai YF, Lin JR, Yu HP. (2019) ''Preoperative Comorbidity and Mortality in Pediatric Liver Transplantation Recipients: A Population-Based Cohort Study'', Asian J Anesthesiol. 56(4):143-152. doi: 10.6859/aja.201812_56(4).0004.

19. Wang D.J., Lee I.S., Chou A.H., Chen C.Y., Ting P.C., Teng Y.H., Lin J.R., Tsai H.I. (2018) '' Non-invasive cardiac output measurement with electrical velocimetry in patients undergoing liver transplantation: comparison of an invasive method with pulmonary thermodilution'', BMC Anesthesiol. 18(1):138. doi: 10.1186/s12871-018-0600-y.

20. Cheng K.H., Lin J.R., Anderson C.S., Lai W.T., Lee T.H.; SRICHS Group. (2018) ''Lipid Paradox in Statin-Naïve Acute Ischemic Stroke But Not Hemorrhagic Stroke'', Front Neurol. 9:541. doi: 10.3389/fneur.2018.00541.

21. Lin H.T., Liu F.C., Lin J.R., Pang S.T., Yu H.P. (2018) ''Impact of the pretransplant dialysis modality on kidney transplantation outcomes: a nationwide cohort study'', BMJ Open. 8(6):e020558. doi: 10.1136/bmjopen-2017-020558.

22. Chen F.T., Liu F.C., Cheng C.W., Lin J.R., Yu H.P. (2018) ''Postoperative Renal Outcomes of Patients Receiving Percutaneous Nephrolithotomy versus Pyelolithotomy: A Population-Based Cohort Study'', Biomed Res Int. 8582901. doi: 10.1155/2018/8582901.

23. Weng Y.M., Ng C.J., Seak C.J., Chien C.Y., Chen K.F., Lin J.R., Chang CJ. (2018) ''One-year survival rate and healthcare costs after cardiac arrest in Taiwan, 2006-2012'', PLoS ONE. 1 13(5):e0196687.

24. Kuo H.Y., Lin J.R., Huang W.H., and Chiang M.L. (2018) ''Clinical outcomes for primary molars treated by different types of pulpotomy: A retrospective cohort study'', Journal of the Formosan Medical Association. 117(1):24-33. doi: 10.1016/j.jfma.2017.02.010.

25. Liu C.H., Lin J.R., Liou C.W., Lee J.D., Peng T.I., Lee M., and Lee T.H. (2017) "Causes of death in different subtypes of ischemic and hemorrhagic stroke", Angiology. doi: 10.1177/0003319717738687.

26. Liu F.C., Ting P.C., Lin J.R., and Yu H.P. (2017) "Immunosuppressants and new onset gallstone disease in patients having undergone renal transplantation", Ther Clin Risk Manag. 13: 1391-1398.

27. Liu F.C., Lin H.T., Lin J.R., and Yu H.P. (2017) "Impact of immunosuppressant therapy on new-onset diabetes in liver transplant recipients", Ther Clin Risk Manag. 13:1043-1051.

28. Hung J.W., Chou C.X., Chang H.F., Wu W.C., Hsieh Y.W., Chen P.C., Yu M.Y., Chang C.C., and Lin J.R., (2017) ''Cognitive effects of weight-shifting controlled exergames in patients with chronic stroke: a pilot randomized comparison trial'', European Journal of Physical and Rehabilitation Medicine. 53(5): 694-702.

29. Yeo L.L Chien S.C., Lin J.R., Liow C.W., Lee J.D., Peng T.I., Luen T.H., Sharma V., Chan B., and Lee T.H. (2017) ''Derivation and validation of a scoring system for intravenous tissue plasminogen activator use in asian patients'', Journal of Stroke and Cerebrovascular Diseases. 26(8): 1695-1703.

30. Lin C.W., Hsu B.R., Tsai J.S., Yang H.M., Lin J.R., Lin C.H., Huang C.H., Hung S.Y., and Huang Y.Y. (2017). "Effect of limb preservation status and body mass index on the survival of patients with limb-threatening diabetic foot ulcers", J. Diabetes Complications. 31(1): 180-185.

31. Chung P.C., Chen H.P., Lin J.R., Liu F.C., and Yu H.P. (2016) "Impact of preoperative chronic renal failure on liver transplantation: A population-based cohort study", Ther Clin Risk Manag. 12: 1855–1860.

32. Cheng C.W., Liu F.C., Lin J.R., Tsai Y.F., Chen H.P., and Yu H.P. (2016) "The impact of hospital/surgeon volume on acute renal failure and mortality in liver transplantation: A nationwide cohort study", PLoS ONE. 11(3): e0152324.

33. Tsai Y.F., Chen H.P., Liu F.C., Liu S.H., Chen C.Y., Cheng C.W., and Lin J.R.** (2016) "Nationwide population-based study reveals increased malignancy risk in Taiwanese liver transplant recipients", Oncotarget. 7(50): 83784-83794.

34. Liu F.C., Lin J.R., Chen H.P., Tsai Y.F., and Yu H.P. (2016) "Prevalence, predictive factors, and survival outcome of new-onset diabetes after liver transplantation: A population-based cohort study", Medicine. 95(25): e3829.

35. Ho W.M., Lin J.R., Wang H.H., Liou C.W., Chang K.C., Lee J.D., Peng T.Y., Yang J.T., Chang Y.J., Chang C.H., and Lee T.H. (2016) "Prediction of in-hospital stroke mortality in critical care unit", Springerplus. 5(1): 1051.

36. Hsu P.Y., Yang S.H., Tsang N.M., Fan K.H., Hsieh C.H., Lin J.R., Hong J.H., Lin Y.C., Chen H.Y., Yang C.T., Yang C.W., and Chen J.L. (2016). "Efficacy of traditional chinese medicine in xerostomia and quality of life during radiotherapy for head and neck cancer: A prospective pilot study", Evid Based Complement Alternat Med. pii: S1056-8727(16)30623-7.

37. Hong C.H., Tu H.P., Lin J.R., and Lee C.H. (2016) "An estimation of the incidence of tuberous sclerosis complex in a nationwide retrospective cohort study (1997–2010)", British Journal of Dermatology. 174(6): 1282-9.

38. Chen H.P., Tsai Y.F., Lin J.R., Liu F.C., and Yu H.P. (2016) "Recipient age and mortality risk after liver transplantation: A population-based cohort study", PLoS ONE. 11(3): e0152324.

39. Liu C.H., Wei Y.C., Lin J.R., Chang C.H., Chang T.Y., Huang K.L., Chang Y.J., Ryu S.J., Lin L.C., and Lee T.H. (2016) "Initial blood pressure is associated with stroke severity and is predictive of admission cost and one-year outcome in different stroke subtypes: a SRICHS registry study", BMC Neurology. 16:27.

40. Lee J.T., Hsieh M.H., Cheng P.J., and Lin J.R. (2016) "The role of xylitol gum chewing in restoring postoperative bowel activity after cesarean section", Biological Research For Nursing. 18(2):167-72

41. Chen H.P., Tsai Y.F., Lin J.R., Liu F.C., and Yu H.P. (2015) "Incidence and outcomes of acute renal failure following liver transplantation: A population-based cohort study", Medicine. 94(52): e2320.

42. Shen S.J., Peng P.Y., Chen H.P., Lin J.R., Lee M.S., and Yu H.P. (2015) "Analgesic effects of intra-articular bupivacaine/intravenous parecoxib combination therapy versus intravenous parecoxib monotherapy in patients receiving total knee arthroplasty: A randomized, double-blind trial", BioMed Research International. 2015:450805.

43. Lo Y.L., Ni Y.L., Wang T.Y., Lin T.Y., Li H.Y., White D.P., Lin J.R., and Kuo H.P. (2015) "Bispectral index in evaluating effects of sedation depth on drug-induced sleep endoscopy", Journal of Clinical Sleep Medicine. 11(9): 1011-1020.

44. Lin J.R., Chang Y.C., and Liu J.P. (2015) '' Evaluation of the parallel line assay for assessment of biosimilar products based on censored data'', Journal of the Chinese Statistical Association. 53(1): 23-37. (JEL, EconLit, CIS)

45. Liu C.H., Chang C.H., Chang T.Y., Huang K.L., Lin J.R., Chen Y.W., Yip B.S., Ryu S.J., Chang Y.J., and Lee T.H. (2015) "Carotid artery stenting improves cerebral hemodynamics regardless of the flow direction of ophthalmic artery", Angiology 66(2):180-6.

* Equal Contributions
** Corresponding Author
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