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Yu- Wen Wen

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1.Name:Yu-Wen Wen
2.Institution:Chang Gung University
3.Position:Assistant Professor
4.Department:Clinical Informatics and Medical Statistics Research Center
5.Address:No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 33302, Taiwan (R.O.C.)
6.Tel(GSM optional)/Fax:03-2118800 ext.3759
7.E-mail:ywwen@mail.cgu.edu.tw
8.Personal Website:

9.Focus of Interest:Biostatistics

10.Fulltime Employment:
2004-2008 Postdoctoral Research Fellow, National Health Research Institute, Taiwan
2008- Assistant Professor, Chang Gung University, Taoyuan, Taiwan


11.Education:Ph.D. in Statistics, National Chengchi University

12.Honors and Awards:None

13.SelectedMain Publications(up to 5 ):
(1) Yu-Wen Wen, Yi-Wen Tsai, David Bin-Chia Wu and Pei-Fen Chen (2013). The Impact of Outliers on Net-Benefit Regression Model in Cost-Effectiveness Analysis. PLoS ONE. 8(6): e65930.
(2) David Bin-Chia Wu, Yi-Wen Tsai and Yu-Wen Wen* (2012). Bayesian Cost-Effectiveness Analysis for Censored Data – An Application to Antiplatelet Therapy. Journal of Medical Economics. 15, 434-443.
(3) Yu-Wen Wen, Yi-Wen Tsai, Weng-Foung Huang, Fei-Yuan Hsaio and Pei-Fen Chen (2011). The Potentially Inappropriate Prescription of New Drug: Thiazolidinediones for Patients with Type II Diabetes in Taiwan. Pharmacoepidemiology and Drug Safety. 20, 20-29.
(4) Yu-Wen Wen, Weng-Foung Huang, Yue-Chune Lee, Ken N. Kuo, Chia-Rung Tsai and Yi-Wen Tsai (2011). Diffusion Patterns of New Anti-diabetic Drugs into Hospitals in Taiwan: The Case of Thiazolidinediones for Diabetes. BMC Health Services Research. 11: 21. (SCI)
(5) Wan-Ting Lin, Yu-Wen Wen, Chun-Ru Chien, Churn-Shiouh Gau, Shao C. Chiang, Fei-Yuan Hsiao (2014). Suboptimal Duration of Granulocyte Colony-stimulating Factors Use and Chemotherapy-induced Neutropenia in Women Diagnosed with Breast Cancer. Clinical Therapeutics. 36, 1287-1294.

14.Patents:None

15.Board Certification:None

16.Ongoing projects:

17.All publications:
1. Chien-Yu Lin, Kang-Hsing Fan, Li-Yu Lee, Chuen Hsueh, Lan Yan Yang, Shu-Hang Ng, Hung-Ming Wang, Chia-Hsun Hsieh, Chih-Hung Lin, Chung-Kan Tsao, Chung-Jan Kang, Tuan-Jen Fang, Li-Ang Lee, Shiang-Fu Huang, Kai-Ping Chang, Tzu-Chen Yen, Ze Yun Tay, Yu-Wen Wen, Shu Ru Lee, Chun-Ta Liao (2020). Precision Adjuvant Therapy Based on Detailed Pathologic Risk Factors for Resected Oral Cavity Squamous Cell Carcinoma: Long-Term Outcome Comparison of CGMH and NCCN Guidelines. International Journal of Radiation Oncology Biology Physics. 106, 916-925. (SCI)

2. Tong-Ling Chien, Fei-Yuan Hsiao, Li-Ju Chen , Yu-Wen Wen , Shu-Wen Lin (2019). Development and Validation of a Risk Scoring System for Cephamycin-Associated Hemorrhagic Events. Scientific Reports. 9: 12905.

3. Shih-Tsung Huang, Yu-Wen Wen, Susan Shur-Fen Gau, Liang-Kung Chen, Fei-Yuan Hsiao (2019). A Group-based Trajectory Analysis of Longitudinal Psychotropic Agent Use and Adverse Outcomes Among Older People. Journal of the American Medical Directors Association. 20, 1579-1586.

4. Y. Chao, Z. Li, Yu-Wen Wen, et al. (2019). Robotic-Assisted Esophagectomy vs Video-Assisted Thoracoscopic Esophagectomy (REVATE): Study Protocol for a Randomized Controlled Trial. Trials 20, 346.
5. Hsien-Yeh Chuang, Yu-Wen Wen, Liang-Kung Chen and Fei-Yuan Hsiao (2019). Drug Use at the End of Life in Older Adults. BMJ Supportive & Palliative care. DOI:10.1136/bmjspcare-2018-001614. (SCI)

6. Yin-Kao Chao, Yu-Wen Wen, Wen-Yu Chuang and Robert J. Cerfolio (2019). Transition from Video-Assisted Thoracoscopic to Robotic Esophagectomy: A Single Surgeon's Experience. Diseases of the Esophagus. DOI: 10.1093/dote/doz033. (SCI)

7. Yin-Kai Chao, Hsin-Yueh Fang, Yu-Wen Wen, Ming -Ju Hsieh and Chih-Tsung Wen (2018). Intraoperative Computed Tomography-Guided Pulmonary Tumour Localization: A Thoracic Surgeon's Learning Curve. European Journal of Cardio-thoracic Surgery, 55, 421-426. (SCI)

8. Chien-Huang Chiu, Yu-Wen Wen and Yin-Kai Chao (2018). Lymph Node Dissection Along the Recurrent Laryngeal Nerves in Patients with Oesophageal Cancer Who Had Undergone Chemoradiotherapy: Is It Safe? European Journal of Cardio-thoracic Surgery, 54, 657-663. (SCI)

9. Zhi-Gang Li, Xiao-Bin Zhang, Yu-Wen Wen, Yun-Hen Liu and Yin-Kai Chao (2018). Incidence and Predictors of Unsuspected Recurrent Laryngeal Nerve Lymph Node Metastases after Neoadjuvant Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma. World Journal of Surgery, 42, 2485-2492. (SCI)

10. Pei-Xuan Liw, Yu-Wen Wen, Chang-Yo Tsai, Hsien-Kun Chang, Chen-Kan Tseng, Tsung-Min Hung and Yin-Kai Chao (2018). Pretreatment Clinical Stage Predicts Locoregional Recurrence in Patients with Esophageal Cancer Who Achieved a Complete Clinical Response to Chemoradiotherapy. The Journal of Thoracic and Cardiovascular Surgery, 155, 2233-2242.e2. (SCI)

11. Ming-Ju Hsieh, Chich-Tsung Wen, Hsin-Yueh Fang, Yu-Wen Wen, Chien-Cheng Lin and Yin-Kai Chao (2018). Learning Curve of Image-Guided Video-Assisted Thoracoscopic Surgery for Small Pulmonary Nodules: A Prospective Analysis of 30 Initial Patients. The Journal of Thoracic and Cardiovascular Surgery, 155, 1825-1832.e1. (SCI)

12. Yin-Kai Chao, Yu-Wen Wen, Hsien-Kun Chang, Chen-Kan Tseng and Yun-Hen Liu (2017). An Analysis of Factors Affecting the Accuracy of Endoscopic Biopsy after Neoadjuvant Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma. European journal of Surgical Oncology, 43, 2366-2373. (SCI)

13. Wen-Han Hsu, Yu-Wen Wen, Liang-Kung Chen and Fei-Yuan Hsiao (2017). Comparative Associations between Measures of Anti-Cholinergic Burden and Adverse Clinical Outcomes. Annals of Family Medicine, 15, 561-569. (SCI)

14. Ying-Huang Tsai, Tsung-Ming Yang, Chieh-Mo Lin, Shu-Yi Huang and Yu-Wen Wen (2017). Trends in Health Care Resource Utilization and Pharmacological Management of Copd in Taiwan from 2004 to 2010. International Journal of Chronic Obstructive Pulmonary Disease, 12, 2787-2793. (SCI)

15. Chun-Ta Liao, Yu-Wen Wen#, Lan Yan Yang, Shu Ru Lee, Shu-Hang Ng, Tsang-Wu Liu, Sen-Tien Tsai, Ming-Hsui Tsai, Jin-Ching Lin, Peir-Rong Chen, Pei-Jen Lou, Cheng Ping Wang, Pen-Yuan Chu, Tzer-Zen Hwang, Yi-Shing Leu, Kuo-Yang Tsai, Shyuang-Der Terng, Tsung-Ming Chen, Cheng-Hsu Wang, Chif-Yen Chien, Wen-Cheng Chen, Li-Yu Lee, Chien-Yu Lin, Huang-Ming Wang, Chia-Hsun Hsieh, Chung-Kan Tsao, Tuan-Jen Fang, Shiang-Fu Huang, Chung-Jan Kang, Kai-Ping Chang and Tzu-Chen Yen (2017). Comparative Clinical Outcomes of Taiwanese Patients with Resected Buccal and Tongue Squamous Cell Carcinomas. Oral Oncology, 67, 95-102. (SCI)

16. Tsun-Jen Wen, Yu-Wen Wen, Chun-Ru Chien, Shao-Chin Chiang, William Wei-Hsu, Li-Jiuan Shen and Fei-Yuan Hsiao (2017). Cost-Effectiveness of Granulocyte Colony-Stimulating Factor Prophylaxis in Chemotherapy-Induced Febrile Neutropenia among Breast Cancer and Non-Hodgkin's Lymphoma Patients under Taiwan's National Health Insurance System. Journal of Evaluation in Clinical Practice, 23, 288-293. (SCI)

17. Chun-Ta Liao, Yu-Wen Wen#, Shu Ru Lee, Tsang-Wu Liu, Sen-Tien Tsai, Ming-Hsui Tsai, Jin-Ching Lin, Pei- Jen Lou, Pen-Yuan Chu, Yi-S.hing Leu, Kuo-Yang Tsai, Shyuang-Der Terng, Tsung-Ming Chen, Cheng-Hsu Wang, Chih-Yen Chien, Wen-Cheng Chen, Li-Yu Lee, Chien-Yu Lin, Hung-Ming Wang, Shu-Hang Ng, Chih-Hung Lin, Tuan-Jen Fang, Shiang-Fu Huang, Chung-Jan Kang, Kai-Ping Chang, Lan Yan Yang, Tzu-Chen Yen and for the Taiwan Oral Cancer Advisory Group (2017). Clinical Outcomes of Taiwanese Patients with Ct4 Oral Cavity Squamous Cell Carcinoma: Toward the Identification of the Optimal Initial Treatment Approach for Ct4b Patients. Annals of Surgical Oncology, 24, 785-793. (SCI)

18. Chun-Ta Liao, Hsin-Ni Chen, Yu-Wen Wen#, Shu Ru Lee, Shu-Hang Ng, Tsang-Wu Liu, Sen-Tien Tsai, Ming-Hsui Tsai, Jin-Ching Lin, Pei-Jen Lou, Cheng-Ping Wang, Pen-Yuan Chu, Yi-Shing Leu, Kuo-Yang Tsai, Shyuang-Der Terng, Tsunag-Ming Chen, Cheng-Hsu Wang, Chih-Yen Chien, Wen-Cheng Chen, Li-Yu Lee, Chien-Yu Lin, Huang-Ming Wang, Chih-Huang Lin, Tuan-Jen Fang, Shiang-Fu Huang, Chung-Jan Kang, Kai-Ping Chang, Lan Yan Yang and Tzu-Chen Yen (2017). Association between the Diagnosis-to-Treatment Interval and Overall Survival in Taiwanese Patients with Oral Cavity Squamous Cell Carcinoma. European Journal of Cancer, 72, 226-234. (SCI)

19. Hsien-Yeh Chuang, Yu-Wen Wen, Liang-Kung Chen and Fei-Yuan Hsiao (2017). Medication Appropriateness for Patients with Dementia Approaching the End of Their Life. Geriatrics & Gerontology International, 17 Suppl 1, 65-74. (SCI)

20. Yin-Kai Chao, Hsien-Kun Chang, Chen-Kan Tseng, Yun-Hen Liu and Yu-Wen Wen* (2017). Development of a Nomogram for the Prediction of Pathological Complete Response after Neoadjuvant Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma. Diseases of the Esophagus, 30, 1-8. (SCI)

21. Chih-Wan Lin, Yu-Wen Wen, Liang-Kung Chen and Fei-Yuan Hsiao (2017). Potentially High-Risk Medication Categories and Unplanned Hospitalizations: A Case-Time-Control Study. Scientific Reports, 7, 41035. (SCI)

22. Chien-Hung Chiu, Yin-Kai Chao, Yu-Wen Wen, Hsien-Kun Chang, Chen-Kan Tseng and Yun-Hen Liu (2017). Unexpected Microscopically Positive Proximal Resection Margins in Esophageal Squamous Cell Carcinoma after Chemoradiotherapy: Predictors and Prognostic Significance. World Journal of Surgery, 41, 191-199. (SCI)

23. Tse-Hsuan Su, Yi-Ling Chan, Jiann-Der Lee, Meng Lee, Leng-Chieh Lin, Yu-Wen Wen* and Tsong-Hai Lee (2016). To Load or Not to Load? Aspirin Loading in Acute Ischemic Stroke: A Study of Clinical Outcomes. Journal of Stroke and Cerebrovascular Diseases, 25, 2439-2447. (SCI)

24. Heng-Yuan Hsu, Yin-Kai Chao, Chia-Hsun Hsieh, Yu-Wen Wen, Hsien-Kun Chang, Chen-Kan Tseng and Yun-Hen Liu (2016). Postoperative Adjuvant Therapy Improves Survival in Pathologic Nonresponders after Neoadjuvant Chemoradiation for Esophageal Squamous Cell Carcinoma: A Propensity-Matched Analysis. The Annals of Thoracic Surgery, 102, 1687-1693. (SCI)

25. Chien-Hung Chiu, Wei-Hsun Chen, Yu-Wen Wen, Chi-Ju Yeh, Yin-Kai Chao, Hsien-Kun Chang, Chen-Kan Tseng and Yun-Hen Liu (2016). Association between the Thoroughness of the Histopathological Examination and Survival in Patients with Esophageal Squamous Cell Carcinoma Who Achieve Pathological Complete Response after Chemoradiotherapy. Diseases of the Esophagus, 29, 634-641. (SCI)

26. Yin-Kai Chao, Chun-Bi Chang, Wen-Yu Chuang, Yu-Wen Wen, Hsien-Kun Chang, Chen-Kan Tseng, Chi-Ju Yeh and Yun-Hen Liu (2015). Correlation between Tumor Regression Grade and Clinicopathological Parameters in Patients with Squamous Cell Carcinoma of the Esophagus Who Received Neoadjuvant Chemoradiotherapy. Medicine, 94, e1407. (SCI)

27. Ying-Huang Tsai, Meng-Jer Hsieh, Chee-Jen Chang, Yu-Wen Wen, Han-Chung Hu, Yen-Nan Chao, Yhu- Chering Huang, Cheng-Ta Yang and Chung-Chi Huang (2015). The 23-Valent Pneumococcal Polysaccharide Vaccine Is Effective in Elderly Adults over 75 Years Old-Taiwan's Ppv Vaccination Program. Vaccine, 33, 2897-2902. (SCI)

28. Yin-Kai Chao, Yu-Wen Wen, Kuo-Sheng Liu, Yi-Chuan Wang, Chih-Wei Wang and Shih-Jung Liu (2015). Biodegradable Drug-Eluting Pellets Provide Steady and Sustainable Cisplatin Release in the Intrapleural Cavity: In Vivo and in Vitro Studies. International Journal of Pharmaceutics, 484, 38-43. (SCI)

29. Weng-Foung Huang, Li-Chuang Chang, Yu-Hsiang Kao, Yu-Wen Wen, Fei-Yuan Hsiao, Li-Ning Peng, Yi-Wen Tsai and Liang-Kung Chen (2015). Prolonged Risk of Subtrochanteric and Diaphyseal Femur Fractures after Discontinuing Alendronate Treatment: A Nationwide Nested Case-Control Study in Taiwan. Journal of Clinical Gerontology and Geriatrics, 6, 54-58. (SCI)

30. Yu-Wen Wen, Hsin Wu and Chee-Jen Chang (2015). Using Dynamic Transmission Modeling to Determine Vaccination Coverage Rate Based on 5-Year Economic Burden of Infectious Disease: An Example of Pneumococcal Vaccine. Value in Health Regional Issues, 6, 46-52.

31. Hsien-Yi Chiu, Wei-Lun Chang, Weng-Foung Huang, Yu-Wen Wen, Yi-Wen Tsai and Tsen-Fang Tsai (2015). Increased Risk of Arrhythmia in Patients with Psoriatic Disease: A Nationwide Population-Based Matched Cohort Study. Journal of the American Academy of Dermatology, 73, 429-438. (SCI)
32. Wan-Hsuan Lu, Yu-Wen Wen, Liang-Kung Chen and Fei-Yuan Hsiao (2015). Effect of Polypharmacy, Potentially Inappropriate Medications and Anticholinergic Burden on Clinical Outcomes: A Retrospective Cohort Study. CMAJ : Canadian Medical Association Journal, 187, E130-E137. (SCI)

33. Yin-Kai Chao, Chi-Ju Yeh, Mu-Hsien Lee, Yu-Wen Wen, Hsien-Kun Chang, Chen-Kan Tseng and Yun-Hen Liu (2015). Factors Associated with False-Negative Endoscopic Biopsy Results after Neoadjuvant Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma. Medicine, 94, e588. (SCI)

34. Fei-Yuan Hsiao, Li-Ning Peng, Yu-Wen Wen, Chih-Kuang Liang, Pei-Ning Wang and Liang-Kung Chen (2015). Care Needs and Clinical Outcomes of Older People with Dementia: A Population-Based Propensity Score-Matched Cohort Study. PloS ONE, 10, e0124973. (SCI)

35. Tan-Wei Chew, Churn-Shiouh Gau, Yu-Wen Wen, Li-Jiuan Shen, C. Daniel Mullins and Fei-Yuan Hsiao (2015). Epidemiology, Clinical Profile and Treatment Patterns of Venous Thromboembolism in Cancer Patients in Taiwan: A Population-Based Study. BMC Cancer, 15, 298. (SCI)
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