Jump to the main content block

Kuan-Fu Chen

1.Name :Kuan-Fu Chen
2.Institution:Chang Gung university / Keelung Chang Gung memorial hospital
3.Position:Associate Professor / Attending Physician and Physician Scientist
4.Department:Clinical Informatics and Medical Statistics Research Center / Emergency Medicine
5.Address:No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 33302, Taiwan
6.Tel/Fax: +886-3-2118800#3574

8.Personal Website:

9.Focus of Interest:
Critical Care and, Emergency Medicine, Infectious Diseases, Clinical Prediction, Systematic review and Meta-Analysis, Machine Learning, Artificial Intelligence, Clinical Epidemiology, Medical Statistics

10.Fulltime Employment:
July 2017-Now: Associate Professor of Clinical Informatics and Medical Statistics Research Center in Chang Gung University
Aug 2013-Now: Assistant Professor of Clinical Informatics and Medical Statistics Research Center in Chang Gung University
May 2010-Now: Physician scientist of department of medical research and development, Chang Gung Memorial Hospital, Keelung
Mar 2006-Aug, 2010: Visiting Research Fellow of Emergency Medicine, Johns Hopkins University, contact person: Richard Rothman, rrothma1@jhmi.edu
Aug 2004-Feb 2006 : Attending physician of Emergency Medicine in Chang Gung Memorial Hospital
Aug 2003-July, 2004: Chief Resident of Emergency Medicine in Chang Gung Memorial Hospital
July 2000-July, 2003: Residency of Emergency Medicine in Chang Gung Memorial Hospital

July 2006-Aug 2010: PhD of Graduate Training Program of Clinical Investigation, Johns Hopkins University, gtpci@jhsph.edu
Sep 1993-June 2000: M.D. of Chung-Shang Medical University, No 110, Sec 1, Chien-Kuo north road, Taichung, 402, Taiwan

12.Honors and Awards:
July 2010 Outstanding Service Award, Advanced Specialty Training Program in Emergency Medicine Research, Department of Emergency Medicine, Johns Hopkins University, 2006-2010

Year 2003 Best Teaching Resident of Chang Gung Memorial Hospital, No 5, Fu-Shin street, Gueishan, Taoyuan, 333, Taiwan

Year 2000 Best Intern of Chung-Shang Medical University, No 110, Sec 1, Chien-Kuo north road, Taichung, 402, Taiwan

13.SelectedMain Publications(up to 5 ):


15.Board Certification:Emergency medicine

16.Ongoing projects:
* Applying machine learning and artificial intelligence on electronic medical record phenotyping incorporating with conventional and novel biomarkers and continuous non-invasive physiological indicators to predict mortality of patients with sepsis
* Adapting the phenome-wide association study, and phylogenetic tree and machine learning algorithms to identify clinically important genetic changes of influenza viruses between Taiwan, North America and Africa
* Utilizing artificial intelligence to assist influenza diagnosis and prediction of severe influenza: incorporating unstructured electronic medical record phenotyping, dynamic modeling, reinforcement learning and ensemble machine learning
* Evaluation of heart rate variability obtained from different non-invasive hemodynamics monitor in predicting septic shock
* Acute Human Influenza Detection and Treatment in Health Care Centers in the United States and Taiwan
* Using physiomarkers obtained from electronic health records, wearable devices, and personal portable devices to develop and update machine learning and transfer learning models to predict patient-centered outcomes

17.All publications:

1.Lin, CC; Chen, KF; Shih, CP; Seak, CJ; Hsu, KH*. The prognostic factors of hypotension after rapid sequence intubation. Am J Emerg Med. 2008 Oct;26(8):845-51.

2.Chen, KF; Gaydos, CA; Rothman, RE. Update on emerging infections: news from the Centers for Disease Control and Prevention. Hospitalized patients with novel influenza A (H1N1) virus infection--California, April-May, 2009.Ann Emerg Med. 2009 Nov;54(5):732-6

3.Hsieh, YH*; Chen, KF; Gaydos, CA; Rothman, RE; Kelen, GD. Antiviral Prescriptions to U.S. Ambulatory Care Visits with a Diagnosis of Influenza before and after High Level of Adamantane Resistance 2005–06 Season. PLoS One. 2010 Jan 28;5(1):e8945.

4.Chen, KF*; Blyn, L; Rothman, RE; Ramachandran, P; Valsamakis, A; Ecker, D; Sampath, R; Gaydos, CA. RT-PCR and Electrospray Ionization Mass Spectrometry (RT-PCR/ESI-MS) for Identifying Acute Viral Upper Respiratory Tract Infections. Diagnostic Microbiology and Infectious Disease. 2011 Feb;69(2):179-86

5.Chen, KF; Rothman, RE; Ramachandran, P; Blyn, L; Sampath, R; Valsamakis, A; Gaydos, CA*. Rapid Identification Viruses from Nasal Pharyngeal Aspirates in Acute Viral Respiratory Infections by RT-PCR and Electrospray Ionization Mass Spectrometry (RT-PCR/ESI-MS). Journal of Virological Methods. 2011 Apr;173(1):60-6.

6.Shih, TY*; Chen, KF (co-first author); Rothman, RE; Hsieh, YH. U.S. National Estimation of Emergency Department Utilization of Patients Given “HIV/AIDS related illness” as Their Primary Diagnosis. HIV Med. 2011 Jul;12(6):343-51.

7.Chen, KF; Colantuoni, E; Siddiqi F; Dinglas VD; Sepulveda KA; Fan E, Pronovost P; Needham DM*. Repeated attempts using different strategies are important for timely contact with study participants. Journal of Clinical Epidemiology. 2011 Oct;64(10):1144-51

8.Yu JH*; Weng YM; Chen KF (co-first author); Chen SY; Lin CC. Triage vital signs predict in-hospital mortality among emergency department patients with acute poisoning: a case control study. BMC Health Serv Res. 2012 Aug 18;12:262.

9.Chiu, MT; Chen, CM*; Lin, CC; Li, CH; Chaou, CH; Chen, HY; Chen, KF. Evaluation of the association between postintubation hypotension and lidocaine administered as a premedication for rapid sequence intubation: A comparison between traditional regression methods and propensity score matching-based method. Journal of Acute Medicine, 2013 Feb; 33-38.

10.Chen, KF*; Hsieh, YH; Gaydos, CA; Valsamakis, A; Rothman, RE. Derivation of a Clinical Prediction Rule to Predict Hospitalization for Influenza in Emergency Departments. Am J Emerg Med, 2013 Mar;31(3):529-34

11.Hsieh, YH*; Kelen, GD; Duglas, AF; Chen, KF; Rothman, RE. Emergency Physician’s Adherence to Center for Disease Control and Prevention Guidance During the 2009 Influenza A H1N1 Pandemic. West J Emerg Med. 2013 Mar; 14(2):191-9.

12.Lynn JJ, Chen KF, Weng YM, Chiu TF*. Risk factors associated with complications in patients with chemotherapy-induced febrile neutropenia in emergency department. Hematol Oncol. 2013 Dec; 31(4):189-96.

13.Schreiber MP, Colantuoni E, Bienvenu OJ, Neufeld KJ, Chen KF, Shanholtz C, Mendez-Tellez PA, Needham DM*. Corticosteroids and transition to delirium in patients with acute lung injury. Crit Care Med. 2014 Jun;42(6):1480-6.

14.Brown, QL*; Linton, SL; Harrell, PT; Mancha, BE; Alexandre, PK.; Chen, KF; Eaton, WW. The Influence of Religious Attendance on Smoking. Subst Use Misuse. 2014 Sep;49(11):1392-9.

15.Yeh, CF; Chen, KF*; Ye, JJ; Huang, CT*. Derivation of a clinical prediction rule for bloodstream infection mortality of patients visiting the emergency department based on predisposition, infection, response and organ dysfunction concept. J Microbiol Immunol Infect. 2014 Dec;47(6):469-77.

16.Tseng JC, Li CH, Chen KF, Chan YL*, Chang SS, Wang FL, Chiu TF, Chen JC. Outcomes of an emergency department intensive care unit in a tertiary medical center in Taiwan: An observational study. J Crit Care. 2015 Jun;30(3):444-8.

17.Lei KF*; Huang CH; Kuo RL*; Chang CK; Chen KF; Tsao KC; Tsang NM. Paper-based enzyme-free immunoassay for rapid detection and subtyping of influenza A H1N1 and H3N2 viruses. Anal Chim Acta. 2015 Jul 9;883:37-44.

18.Wu SH, Chen KF, Chan YL*. Severe hydrogen sulfide intoxication treated with therapeutic hypothermia. Am J Emerg Med. 2015 Sep;33(9):1327.e1-2.

19.Cheng CH*, Chan PS, Hsieh YW, Chen KF. A meta-analysis of mismatch negativity in children with attention deficit-hyperactivity disorders. Neurosci Lett. 2016 Jan 26;612:132-7.

20.Hsu CY, Liu SH, Chao CH, Chan YL, Tsai TC, Chen LM, Wu CC, Chen KF*. STROBE-compliant article: Blood Transfusions within the First 24 Hours of Hospitalization Did Not Impact Mortality Among Patients with Severe Sepsis. Medicine (Baltimore). 2016 Jan;95(4):e2601.

21.Tsou YK, Lee MS, Chen KF, Lin CH*, Sung KF, Wu CC. Double-balloon enteroscopy-assisted endoscopic retrograde cholangiography for Roux-en-Y reconstruction patients with papilla of Vater or bilioenteric anastomosis. Scand J Gastroenterol. 2016 Jan;51(1):95-102.

22.Chen KF, Chaou CH, Jiang JY, Yu HW, Meng YH, Tang WC, Wu CC*. Diagnostic Accuracy of Lipopolysaccharide-Binding Protein as Biomarker for Sepsis in Adult Patients: A Systematic Review and Meta-Analysis. PLoS One. 2016 Apr 7;11(4):e0153188.

23.Li CJ*, Syue YJ, Lin YR, Cheng HH, Cheng FJ, Tsai TC, Chen KF*, Lee CH. Influence of CT utilisation on patient flow in the emergency department: a retrospective 1-year cohort study. BMJ Open. 2016 May 4;6(5):e010815.

24.Chen CK, Lin SC, Wu CC, Chen LM, Tzeng IS, Chen KF*. STARD-compliant article: The utility of red cell distribution width to predict mortality for septic patients visiting the emergency department. Medicine (Baltimore). 2016 Jun;95(24):e3692.

25.Liu SH, Chen KF, Chen CJ, Lin YH, Huang YC*. Intermittent nasal carriage with Staphylococcus aureus within a menstrual cycle: Results from a prospective cohort of healthy carriers. Medicine (Baltimore). 2016 Jun;95(26):e4040.

26. Tzeng IS, Liu SH, Chen KF, Wu CC, Chen JC*. Impact of performance grading on annual numbers of acute myocardial infarction-associated emergency department visits in Taiwan: Results of segmented regression analysis. Medicine (Baltimore). 2016 Oct;95(42):e4937.

27.Chen KF, Liu SH, Li CH, Wu CC, Chaou CH, Tzeng IS, Hsieh YH, Blaney GN, Liu ZY, Han ST*, Chan YL*. Development and validation of a parsimonious and pragmatic CHARM score to predict mortality in patients with suspected sepsis. Am J Emerg Med. 2016 Oct; S0735-6757 (16):30801-4.

28.Chou HL, Han ST, Yeh CF, Tzeng IS, Hsieh TH, Wu CC, Kuan JT, Chen KF*. Systemic inflammatory response syndrome is more associated with bacteremia in elderly patients with suspected sepsis in emergency departments. Medicine (Baltimore). 2016 Dec;95(49):e5634.

29.Tzeng IS, Liu SH, Chiou YT, Huang CH, Lee CJ, Chien CY, Hsu SC, Weng YM, Chen KF*, Chen JC*. Predicting emergency departments visit rates from septicemia in Taiwan using an age-period-cohort model, 1998 to 2012. Medicine (Baltimore). 2016 Dec;95(50):e5598.

30.Chao HY, Liu PH, Lin SC, Chen CK, Chen JC, Chan YL, Wu CC, Blaney GN, Liu ZY, Wu CJ, Chen KF*. Association of in-hospital mortality and dysglycemia in septic patients. PLOS ONE. 2017 Jan 20;12(1):e0170408.

31.Chien CY, Chen YH, Han ST, Blaney GN., Huang TS, Chen KF*. The Number of Displaced Rib Fractures is More Predictive for Complications in Chest Trauma Patients. Scandinavian Journal of Trauma Resuscitation and Emergency Medicine. 2017 Feb 28;25(1):19.

32.Chiu CY, Chan YL, Tsai YS, Chen SA, Wang CJ, Chen KF, Chung IF. Airway Microbial Diversity is Inversely Associated with Mite-Sensitized Rhinitis and Asthma in Early Childhood. Sci Rep. 2017 May 12;7(1):1820.

33.Chien CH, Chen LW, Lin CL, Chang SW, Shyu YC, Chen KF, Chen SW, Hu CC, Yu CY, Chien RN. Unawareness of Hepatitis B Virus Infection confers on Higher Rate of Metabolic Syndrome: A Community-based Study. Sci Rep. 2017 Aug 29;7(1):9869.

34.Chan YL, Han ST, Li CH, Wu CC, Chen KF*. Transfusion of Red Blood Cells to Patients with Sepsis. Int J Mol Sci. 2017 Sep 11;18(9).

35.Wu CC, Lan HM, Han ST, Chaou CH, Yeh CF, Liu SH, Li CH, Blaney GN 3rd, Liu ZY, Chen KF*. Comparison of diagnostic accuracy in sepsis between presepsin, procalcitonin, and C-reactive protein: a systematic review and meta-analysis. Ann Intensive Care. 2017 Sep 6;7(1):91.

36.Cheng CT, Yeh CN*, Chiang KC, Yeh TS, Chen KF, Chen SW. Effects of cholecystectomy on recurrent biliary complications after endoscopic treatment of common bile duct stone: a population-based cohort study. Surg Endosc. 2018 Apr;32(4):1793-1801.

37.Weng YM, Ng CJ, Seak CJ, Chien CY, Chen KF, Lin JR, Chang CJ. One-year survival rate and healthcare costs after cardiac arrest in Taiwan, 2006-2012. PLoS One. 2018 May 1; 13(5):e0196687.

38.Yeh CF, Wu CC, Liu SH, Chen KF*. Comparison of the accuracy of neutrophil CD64, procalcitonin, and C-reactive protein for sepsis identification: a systematic review and meta-analysis. Ann Intensive Care. 2019 Jan 8; 9(1):5.

39.Chen KF, Tsai MY, Wu CC, Han ST. Effectiveness of Treatments and Diagnostic Tools and Declining Mortality in Patients With Severe Sepsis: A 12-Year Population-Based Cohort Study. J Intensive Care Med. 2020 Dec;35(12):1418-1425.

40.Lin CC, Wu CC, Chen CD, Chen KF*. Could we employ the queueing theory to improve efficiency during future mass causality incidents? Scand J Trauma Resusc Emerg Med. 2019 Apr 11; 27(1):41.

41.Sung CM*, Lin YF*, Chen KF*, Ke HM, Huang HY, Gong YN, Tsai WS, Lu MJ, Cheng HT, Lin CY, Kuo CJ, Tsai IJ, Hsieh SY. Predicting Clinical Outcomes of Cirrhosis Patients With Hepatic Encephalopathy From the Fecal Microbiome. Cell Mol Gastroenterol Hepatol. 2019 Apr 18. pii: S2352-345X(19)30047-5.

42.Wei YC, Chen KF, Wu CL, Lee TW, Liu CH, Shyu YC, Lin CP. Stroke Rate Increases Around the Time of Cancer Diagnosis. Frontiers in Neurology. 2019 June 07; 10:579.

43.Martinez-Sobrido L, Blanco-Lobo P, Rodriguez L, Fitzgerald T, Zhang H, Nguyen P, Anderson CS, Holden-Wiltse J, Bandyopadhyay S, Nogales A, DeDiego ML, Wasik BR, Miller BL, Henry C, Wilson PC, Sangster MY, Treanor JJ, Topham DJ, Byrd-Leotis L, Steinhauer DA, Cummings RD, Luczo JM, Tompkins SM, Sakamoto K, Jones CA, Steel J, Lowen AC, Danzy S, Tao H, Fink AL, Klein SL, Wohlgemuth N, Fenstermacher KJ, El Najjar F, Pekosz A, Sauer L, Lewis MK, Shaw-Saliba K, Rothman RE, Liu ZY, Chen KF, Parrish CR, Voorhees IEH, Kawaoka Y, Neumann G, Chiba S, Fan S, Hatta M, Kong H, Zhong G, Wang G, Uccellini MB, García-Sastre A, Perez DR, Ferreri LM, Herfst S, Richard M, Fouchier R, Burke D, Pattinson D, Smith DJ, Meliopoulos V, Freiden P, Livingston B, Sharp B, Cherry S, Dib JC, Yang G, Russell CJ, Barman S, Webby RJ, Krauss S, Danner A, Woodard K, Peiris M, Perera RAPM, Chan MCW, Govorkova EA, Marathe BM, Pascua PNQ, Smith G, Li YT, Thomas PG, Schultz-Cherry S. Characterizing Emerging Canine H3 Influenza Viruses. PLoS Pathog. 2020 Apr 14;16(4):e1008409.

44.Gong YN, Tsao KC, Hsiao MJ, Huang CG, Huang PN, Huang PW, Lee KM, Liu YC, Yang SL, Kuo RL, Chen KF, Liu YC, Huang SY, Huang HI, Liu MT, Yang JR, Chiu CH, Yang CT, Chen GW, Shih SR. SARS-CoV-2 Genomic Surveillance in Taiwan Revealed Novel ORF8-deletion Mutant and Clade Possibly Associated With Infections in Middle East. Emerg Microbes Infect. Emerg Microbes Infect. 2020 Dec;9(1):1457-1466.

45.Lee EP, Chu SC, Hsia SH, Chen KF, Chan OW, Lin CY, Su YT, Lin JJ, Wu HP. Comparison of Predictive Powers for Mortality between Systemic Vascular Resistance Index and Serum Lactate in Children with Persistent Catecholamine-Resistant Shock. Biomed Res Int. 2020 Jun 19;2020:1341326.

46.Boyd DF, Allen EK, Randolph AG, Guo XJ, Weng Y, Sanders CJ, Bajracharya R, Lee NK, Guy CS, Vogel P, Guan W, Li Y, Liu X, Novak T, Newhams MM, Fabrizio TP, Wohlgemuth N, Mourani PM; PALISI Pediatric Intensive Care Influenza (PICFLU) Investigators, Wight TN, Schultz-Cherry S, Cormier SA, Shaw-Saliba K, Pekosz A, Rothman RE, Chen KF, Yang Z, Webby RJ, Zhong N, Crawford JC, Thomas PG. Exuberant fibroblast activity compromises lung function via ADAMTS4. Nature. 2020 Nov;587(7834):466-471.

47.Hung SK, Lan HM, Han ST, Wu CC, Chen KF*. Current Evidence and Limitation of Biomarkers for Detecting Sepsis and Systemic Infection. Biomedicines. 2020 Nov 12;8(11):494.

48.Chien CY, Yan JL, Han ST, Chen JT, Huang TS, Chen YH, Wang CY, Lee YL, Chen KF*. Inferior Vena Cava Volume Is an Independent Predictor of Massive Transfusion in Patients With Trauma. J Intensive Care Med. 2021 Apr;36(4):428-435.

49.Chen CB, Chen KF, Chien CY, Kuo CW, Goh ZNL, Seak CK, Seak JC, Seak CJ; SPOT Consortium. Shoulder strap fixation of LUCAS-2 to facilitate continuous CPR during non-supine (stair) stretcher transport of OHCAs patients. Sci Rep. 2021 May 10;11(1):9858.

50.Liu H, Gong YN, Shaw-Saliba K, Mehoke T, Evans J, Liu ZY, Lewis M, Sauer L, Thielen P, Rothman R, Chen KF*, Pekosz A*. Differential Disease Severity and Whole Genome Sequence Analysis for Human Influenza A/H1N1pdm Virus in 2015-2016 Influenza Season. Virus Evolution, 2021 May 18;7(1):veab044.

51.Sung WH, Yeh KW, Huang JL, Su KW, Chen KF, Wu CC, Tsai MH, Hua MC, Liao SL, Lai SH, Chiu CY. Longitudinal changes in body mass index Z-scores during infancy and risk of childhood allergies. J Microbiol Immunol Infect. 2021 Oct 25:S1684-1182(21)00228-0.

52.Chen CK, Yeh YT, Mégarbane B, Chen YC, Chen KF, Chang CH, Lin CC. A novel flowchart to predict mortality and analyse effectiveness of routinely used pharmacological regimens in paraquat poisoning. Basic Clin Pharmacol Toxicol. 2021 Dec;129(6):496-503.

53.Lin WH, Chiu HC, Chen KF, Tsao KC, Chen YY, Li TH, Huang YC, Hsieh YC. Molecular detection of respiratory pathogens in community-acquired pneumonia involving adults. J Microbiol Immunol Infect. 2021 Dec 16:S1684-1182(21)00270-X.

54.Souza CK, Anderson TK, Chang J, Venkatesh D, Lewis NS, Pekosz A, Shaw-Saliba K, Rothman RE, Chen KF, Vincent AL. Antigenic Distance between North American Swine and Human Seasonal H3N2 Influenza A Viruses as an Indication of Zoonotic Risk to Humans. J Virol. 2022 Jan 26;96(2):e0137421.

55.Liu KT, Gong YN, Huang CG, Huang PN, Yu KY, Lee HC, Lee SC, Chiang HJ, Kung YA, Lin YT, Hsiao MJ, Huang PW, Huang SY, Wu HT, Wu CC, Kuo RL, Chen KF, Hung CT, Oguntuyo KY, Stevens CS, Kowdle S, Chiu HP, Lee B, Chen GW, Shih SR. Quantifying Neutralizing Antibodies in Patients with COVID-19 by a Two-Variable Generalized Additive Model. mSphere. 2022 Feb 23;7(1):e0088321.

56.Zapf AJ, Hardick J, McBryde B, Sauer LM, Fenstermacher KZJ, Ricketts EP, Lin YC, Chen KF*, Hsieh YH, Dugas A, Shaw-Saliba K, Pekosz A*, Gaydos CA, Rothman RE; Emergency Department National Network Influenza Investigators. Impact of coinfection status and comorbidity on disease severity in adult emergency department patients with influenza B. Influenza Other Respir Viruses. 2022 Mar;16(2):236-246.

57.Chao HY, Wu CC, Singh A, Shedd A, Wolfshohl J, Chou EH, Huang YC, Chen KF*. Using Machine Learning to Develop and Validate an In-Hospital Mortality Prediction Model for Patients with Suspected Sepsis. Biomedicines. 2022 Mar 29;10(4):802.

58.Su PY, Wei YC, Luo H, Liu CH, Huang WY, Chen KF, Lin CP, Wei HY, Lee TH. Machine Learning Models for Predicting Influential Factors of Early Outcomes in Acute Ischemic Stroke: Registry-Based Study. JMIR Med Inform. 2022 Mar 25;10(3):e32508.

59.Wei YC, Huang WY, Jian CY, Hsu CH, Hsu CC, Lin CP, Cheng CT, Chen YL, Wei HY, Chen KF*. Semantic segmentation guided detector for segmentation, classification, and lesion mapping of acute ischemic stroke in MRI images. Neuroimage Clin. 2022 May 12;35:103044.

60.Tsai TY, Cheong KM, Su YC, Shih MC, Chau SW, Chen MW, Chen CT, Lee YK, Sun JT, Chen KF, Chen KC, Chou EH. Ultrasound-Guided Femoral Nerve Block in Geriatric Patients with Hip Fracture in the Emergency Department. J Clin Med. 2022 May 14;11(10):2778.

61.Yang TH, Chen KF, Gao SY, Lin CC. Risk factors associated with peri-intubation cardiac arrest in the emergency department. Am J Emerg Med. 2022 Jun 11;58:229-234.
Click Num: