本中心研究成員均與國內外大學、研究機構或醫院之研究人員或臨床醫師有長期性的研究合作，過去五年間之研究成果卓著，已發表在國際知名的研究期刊上，有關各位教授的專業傑出表現，請參閱其個人網頁。

本中心近二年之研究成果如下：

* Chun-Bing Chen, Tsun-Hao Hsu, Rosaline Chung-Yee Hui, Chun-Wei Lu, Wei-Ti Chen, Pin-Hsuan Chiang, Chuang-Wei Wang, Shiow-Shuh Chuang, Jui-Yung Yang, Shih-Yi Yang, Shu-Ying Chang, Yen-Chang Hsiao, Kuo-Chin Kao, Han-Chung Hu, Ting-Shu Wu, Chao-Wei Hsu, David Hui-Kang Ma, Shin-Yi Chen, Ya-Chung Tian, Chi-Yuan Cheng, Chi-Hua Chen, Min-Hui Chi, Ming-Ying Wu, Ren-Feng Liu, Chi-Hui Wang, Ya-Ching Chang, Jing-Yi Lin, Hsin-Chun Ho, Yang Yu-Wei Lin, Chee Jen Chang, Yu-Jr Lin, Cheng-Lung Ku, Shuen-Iu Hung, Wen-Hung Chung*, Taiwan Severe Cutaneous Adverse Reaction Consortium. 2020,08. Disseminated intravascular coagulation in Stevens-Johnson syndrome and toxic epidermal necrolysis. J Am Acad Dermatol. 84(6):1782-1791. (SCI)

* Hsien-Yi Chiu, Chee Jen Chang, Yu Jr Lin, Tsen-Fang Tsai*. 2020,09. National trends in incidence, mortality, hospitalizations, and expenditures for pemphigus in Taiwan. Journal of Dermatological Science. 99(3):203-208. (SCI)

* Tzu-Yu Lin, Chi-Yuan Cheng, Yi-Chia Chen, Shu-Chen Chang, Chi-Hua Chen*, Chee-Jen Chang. 2020,10. The cancer-specific survival benefit of adjuvant chemotherapy for patients aged 75 or older with stage III colon cancer. Formosa Journal of Clinical Pharmacy. 28(4):320-334.

*  Chih-Hsiang Chang, Sheng-Hsun Lee, Yu-Chih Lin, Yi-Chun Wang, Chee-Jen Chang, Pang-Hsin Hsieh*. 2020,11. Increased periprosthetic hip and knee infection projected from 2014 to 2035 in Taiwan. Journal of Infection and Public Health. 13(11):1768-1773. (SCI)

*  Chih-Hsiang Chang, Chee-Jen Chang, Yi-Chun Wang, Chih-Chien Hu, Yuhan Chang, Pang-Hsin Hsieh, Dave W Chen*. 2020,9-12. Increased incidence, morbidity, and mortality in cirrhotic patients with hip fractures: A nationwide population-based study. J Orthop Surg (Hong Kong). 28(3):2309499020918032. (SCI)

* Chen KF, Tsai MY, Wu CC, Han ST. Effectiveness of Treatments and Diagnostic Tools and Declining Mortality in Patients With Severe Sepsis: A 12-Year Population-Based Cohort Study. J Intensive Care Med. 2020 Dec;35(12):1418-1425.

* Lin CC, Wu CC, Chen CD, Chen KF*. Could we employ the queueing theory to improve efficiency during future mass causality incidents? Scand J Trauma Resusc Emerg Med. 2019 Apr 11; 27(1):41.

* Sung CM*, Lin YF*, Chen KF*, Ke HM, Huang HY, Gong YN, Tsai WS, Lu MJ, Cheng HT, Lin CY, Kuo CJ, Tsai IJ, Hsieh SY. Predicting Clinical Outcomes of Cirrhosis Patients With Hepatic Encephalopathy From the Fecal Microbiome. Cell Mol Gastroenterol Hepatol. 2019 Apr 18. pii: S2352-345X(19)30047-5.

* Wei YC, Chen KF, Wu CL, Lee TW, Liu CH, Shyu YC, Lin CP. Stroke Rate Increases Around the Time of Cancer Diagnosis. Frontiers in Neurology. 2019 June 07; 10:579.

* Martinez-Sobrido L, Blanco-Lobo P, Rodriguez L, Fitzgerald T, Zhang H, Nguyen P, Anderson CS, Holden-Wiltse J, Bandyopadhyay S, Nogales A, DeDiego ML, Wasik BR, Miller BL, Henry C, Wilson PC, Sangster MY, Treanor JJ, Topham DJ, Byrd-Leotis L, Steinhauer DA, Cummings RD, Luczo JM, Tompkins SM, Sakamoto K, Jones CA, Steel J, Lowen AC, Danzy S, Tao H, Fink AL, Klein SL, Wohlgemuth N, Fenstermacher KJ, El Najjar F, Pekosz A, Sauer L, Lewis MK, Shaw-Saliba K, Rothman RE, Liu ZY, Chen KF, Parrish CR, Voorhees IEH, Kawaoka Y, Neumann G, Chiba S, Fan S, Hatta M, Kong H, Zhong G, Wang G, Uccellini MB, García-Sastre A, Perez DR, Ferreri LM, Herfst S, Richard M, Fouchier R, Burke D, Pattinson D, Smith DJ, Meliopoulos V, Freiden P, Livingston B, Sharp B, Cherry S, Dib JC, Yang G, Russell CJ, Barman S, Webby RJ, Krauss S, Danner A, Woodard K, Peiris M, Perera RAPM, Chan MCW, Govorkova EA, Marathe BM, Pascua PNQ, Smith G, Li YT, Thomas PG, Schultz-Cherry S. Characterizing Emerging Canine H3 Influenza Viruses. PLoS Pathog. 2020 Apr 14;16(4):e1008409.

* Gong YN, Tsao KC, Hsiao MJ, Huang CG, Huang PN, Huang PW, Lee KM, Liu YC, Yang SL, Kuo RL, Chen KF, Liu YC, Huang SY, Huang HI, Liu MT, Yang JR, Chiu CH, Yang CT, Chen GW, Shih SR. SARS-CoV-2 Genomic Surveillance in Taiwan Revealed Novel ORF8-deletion Mutant and Clade Possibly Associated With Infections in Middle East. Emerg Microbes Infect. Emerg Microbes Infect. 2020 Dec;9(1):1457-1466.

* Lee EP, Chu SC, Hsia SH, Chen KF, Chan OW, Lin CY, Su YT, Lin JJ, Wu HP. Comparison of Predictive Powers for Mortality between Systemic Vascular Resistance Index and Serum Lactate in Children with Persistent Catecholamine-Resistant Shock. Biomed Res Int. 2020 Jun 19;2020:1341326.

* Boyd DF, Allen EK, Randolph AG, Guo XJ, Weng Y, Sanders CJ, Bajracharya R, Lee NK, Guy CS, Vogel P, Guan W, Li Y, Liu X, Novak T, Newhams MM, Fabrizio TP, Wohlgemuth N, Mourani PM; PALISI Pediatric Intensive Care Influenza (PICFLU) Investigators, Wight TN, Schultz-Cherry S, Cormier SA, Shaw-Saliba K, Pekosz A, Rothman RE, Chen KF, Yang Z, Webby RJ, Zhong N, Crawford JC, Thomas PG. Exuberant fibroblast activity compromises lung function via ADAMTS4. Nature. 2020 Nov;587(7834):466-471.

* Hung SK, Lan HM, Han ST, Wu CC, Chen KF*. Current Evidence and Limitation of Biomarkers for Detecting Sepsis and Systemic Infection. Biomedicines. 2020 Nov 12;8(11):494.

* Shih-Chiang Huang, Kwai-Fong Ng, Ian Yi-Feng Chang, Chee-Jen Chang, Yi-Chun Chao, Shu-Chen Chang, Min-Chi Chen, Ta-Sen Yeh, Tse-Ching Chen*. 2021,01. The clinicopathological significance of SWI/SNF alterations in gastric cancer is associated with the molecular subtypes. PLOS ONE. 16(1):e0245356. (SCI)

* Chun-Bing Chen, Kang-Ling Kuo, Chuang-Wei Wang, Chun-Wei Lu, Rosaline Chung-Yee Hui, Kun-Lin Lu, Wan-Chun Chang, Wei-Ti Chen, Fu Yun, Yu-Chuan Teng, Hua-En Lee, Jing-Yi Lin, Hsin-Chun Ho, Min-Hui Chi, Yang Yu-Wei Lin, Chee Jen Chang, Yu Lin Jr, Cheng-Lung Ku, Shuen-Iu Hung, Ya-Ching Chang, Wen-Hung Chung*, Taiwan Severe Cutaneous Adverse Reaction Consortium. 2021,03. Detecting Lesional Granulysin Levels for Rapid Diagnosis of Cytotoxic T lymphocyte-Mediated Bullous Skin Disorders. J Allergy Clin Immunol Pract. 9(3):1327-1337.e3. (SCI)

*  Shyue-Luen Chang, Sindy Hu, Yau-Li Huang, Mei-Ching Lee, Wen-Hung Chung, Chun-Yu Cheng, Yen-Chang Hsiao, Chee Jen Chang, Shu Ru Lee, Su-Wei Chang, Yu-Wen Wen*. 2021,03. Treatment of Varicose Veins Affects the Incidences of Venous Thromboembolism and Peripheral Artery Disease. Circ Cardiovasc Interv. 14(3):e010207. (SCI)

*  Chen CB, Chen YE, Chu MT, Wang CW, Hui RC, Lu CW, Hsiao YP, Chu CY, Chang MM, Cheung CM, Cheng CY, Wang YW, Lin YJ, Chang CJ, Hung SI*, Chung WH*, Taiwan Severe Cutaneous Adverse Reaction Consortium. 2021,03. The risk of anti-osteoporotic agent-induced severe cutaneous adverse drug reactions and their association with HLA. J Eur Acad Dermatol Venereol. 35(3):712-720. (SCI)

*  Li-Chung Chiu, Li-Pang Chuang, Shaw-Woei Leu, Yu-Jr Lin, Chee-Jen Chang, Hsin-Hsien Li, Feng-Chun Tsai, Chih-Hao Chang, Chen-Yiu Hung, Shih-Wei Lin, Han-Chung Hu, Chung-Chi Huang, Huang-Pin Wu, Kuo-Chin Kao*. 2021,03. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome: Propensity Score Matching. Membranes. 11(6):393. (SCI)

*  Chuang-Wei Wang, Wichittra Tassaneeyakul, Chun-Bing Chen, Wei-Ti Chen, Yu-Chuan Teng, Cheng-Yang Huang, Chonlaphat Sukasem, Chun-Wei Lu, Yun-Shien Lee, Siew-Eng Choon, Nontaya Nakkam, Rosaline Chung-Yee Hui, Yen-Hua Huang, Ya-Ching Chang, Yang Yu-Wei Lin, Chee-Jen Chang, Tsu-Man Chiu, Wasun Chantratita, Parinya Konyoung, Chaw-Ning Lee, Jettanong Klaewsongkram, Ticha Rerkpattanapipat, Warayuwadee Amornpinyo, Niwat Saksit, Pawinee Rerknimitr, Huang Yu Huei, Shang-Hong Lin, Chao-Kai Hsu, Wen-Lang Fan, Cheng-Chi Chan, Yu-Jr Lin, Shuen-Iu Hung*, Wen-Hung Chung*, Taiwan/Asian Severe Cutaneous Adverse Reaction Consortium. 2021,04. Whole Genome Sequencing Identifies Genetic Variants Associated with Co-trimoxazole Hypersensitivity in Asians. Journal of Allergy and Clinical Immunology. 147(4):1402-1412. (SCI)

*  Jui-Fan Chiang, Ming-Hui Sun*, Kuan-Jen Chen, Wei-Chi Wu, Chi-Chun Lai, Chee-Jen Chang, Yu-Jr Lin, Shu-Chen Chang, Hung-Yu Huang, Ning-Hung Chen, Hsueh-Yu Li. 2021,06. Association between obstructive sleep apnea and diabetic macular edema in patients with type 2 diabetes. Am J Ophthalmol. 226:217-225. (SCI)

*  Chih-Kuo Lee, Tzung-Dau Wang*, Hsiao-Ting Juang, Shu-Chen Chang, Heng-Yu Pan, Donna Shu-Han Lin, Chee-Jen Chang*. 2021,07. Efficacy and safety of ticagrelor versus clopidogrel in patients with non-ST-elevation myocardial infarction in Taiwan. Scientific Reports. 11:14150. (SCI)

* Hung-Yu Huang, Chee-Jen Chang, Shu-Chen Chang, Li-Fu Li*. 2021,08. Author Reply to letter to the editor "clinical outcomes and prognostic factors for prolonged mechanical ventilation in patients with acute stroke and brain trauma". J Formos Med Assoc. 120(8):1658-1659. (SCI)

* Sheng-Hsun Lee,Yu-Chih Lin, Chee-Jen Chang, Chih-Yun Fan Chiang, Szu-Yuan Chen, Yu-Han Chang, Pang-Hsin Hsieh, Chih-Hsiang Chang*. 2021,10. Outcome and Cost Analysis of Primary Total Knee Arthroplasty in End-stage Renal Disease Patients: A Nationwide Population-based Study. Biomed J. 44(5):620-626. (SCI)

* Oh SL, Chen CM, Wu YR, Valdes Hernandez M, Tsai CC, Cheng JS, Chen YL, Wu YM, Lin YC, Wang JJ. Fixel-Based Analysis Effectively Identifies White Matter Tract Degeneration in Huntington's Disease. Front Neurosci. 2021;15:711651.

* Chen CJ, Cheng JS, Wang HE, Huang CW, Hu JH, Chen WT, Chang MY, Ku HP, Lin CY, Chien RN, Chang ML. Identification of the Representative Primary Biliary Cholangitis Cohort in Taiwan: A Comparison of Four Nationwide Cohorts. J Clin Med. 2021;10(11):2226.

* Cheng JS, Hu JH, Chang MY, Lin MS, Ku HP, Chien RN, Chang ML. Hepatitis C-associated late-onset schizophrenia: a nationwide, population-based cohort study. J Psychiatry Neurosci. 2021;46(6):E583-E591.

*  Cheng JS, Lin YS, Hu JH, Chang MY, Ku HP, Chien RN, Chang ML. Impact of Interferon-Based Therapy on Hepatitis C-Associated Rheumatic Diseases: A Nationwide Population-Based Cohort Study. J Clin Med. 2021;10(4):817.

* Chu YY, Cheng JS, Wu TS, Chen CW, Chang MY, Ku HP, Chien RN, Chang ML. Association between Hepatitis C Virus Infection and Esophageal Cancer: An Asian Nationwide Population-Based Cohort Study. J Clin Med. 2021;10(11):2395.

* Nguyen TT, Cheng JS, Chen YL, Lin YC, Tsai CC, Lu CS, Weng YH, Wu YM, Hoang NT, Wang JJ. Fixel-Based Analysis of White Matter Degeneration in Patients With Progressive Supranuclear Palsy or Multiple System Atrophy, as Compared to Parkinson's Disease. Front Aging Neurosci. 2021;13:625874.

*  Wu MH, Lin YS, Wu C, Lee CY, Chen YC, Huang TJ, Cheng JS. Timing of Bisphosphonate (Alendronate) Initiation after Surgery for Fragility Fracture: A Population-Based Cohort Study. J Clin Med. 2021 Jun 8;10(12):2541.

* Chien CY, Yan JL, Han ST, Chen JT, Huang TS, Chen YH, Wang CY, Lee YL, Chen KF*. Inferior Vena Cava Volume Is an Independent Predictor of Massive Transfusion in Patients With Trauma. J Intensive Care Med. 2021 Apr;36(4):428-435.

* Chen CB, Chen KF, Chien CY, Kuo CW, Goh ZNL, Seak CK, Seak JC, Seak CJ; SPOT Consortium. Shoulder strap fixation of LUCAS-2 to facilitate continuous CPR during non-supine (stair) stretcher transport of OHCAs patients. Sci Rep. 2021 May 10;11(1):9858.

* Liu H, Gong YN, Shaw-Saliba K, Mehoke T, Evans J, Liu ZY, Lewis M, Sauer L, Thielen P, Rothman R, Chen KF*, Pekosz A*. Differential Disease Severity and Whole Genome Sequence Analysis for Human Influenza A/H1N1pdm Virus in 2015-2016 Influenza Season. Virus Evolution, 2021 May 18;7(1):veab044.

* Sung WH, Yeh KW, Huang JL, Su KW, Chen KF, Wu CC, Tsai MH, Hua MC, Liao SL, Lai SH, Chiu CY. Longitudinal changes in body mass index Z-scores during infancy and risk of childhood allergies. J Microbiol Immunol Infect. 2021 Oct 25:S1684-1182(21)00228-0.

* Chen CK, Yeh YT, Mégarbane B, Chen YC, Chen KF, Chang CH, Lin CC. A novel flowchart to predict mortality and analyse effectiveness of routinely used pharmacological regimens in paraquat poisoning. Basic Clin Pharmacol Toxicol. 2021 Dec;129(6):496-503.

* Lin WH, Chiu HC, Chen KF, Tsao KC, Chen YY, Li TH, Huang YC, Hsieh YC. Molecular detection of respiratory pathogens in community-acquired pneumonia involving adults. J Microbiol Immunol Infect. 2021 Dec 16:S1684-1182(21)00270-X.

* Hung-Yu Huang, Chung-Shu Lee, Tzu-Hsuan Chiu, Hsiang Hsuan Chen, Li-Yi Chan, Chee-Jen Chang, Shu-Chen Chang, Han-Chung Hu, Kuo-Chin Kao, Ning-Hung Chen, Shu-Min Lin, Li-Fu Li*. 2022,01. Clinical outcomes and prognostic factors for prolonged mechanical ventilation in patients with acute stroke and brain trauma. J. Formos. Med. Assoc. 121(1 Pt 1):162-169. (SCI)

* Hsu JY, Chang CJ, Cheng JS. Survival, treatment regimens and medical costs of women newly diagnosed with metastatic triple-negative breast cancer. Sci Rep. 2022;12(1):729.

*  Cheng JS, Chen TC, Chen TD, Ku HP, Huang SW, Wu TS, Chien RN, Chang ML. Association between breast cancer and hepatitis C: A joint study of hospitalized patients and nationwide cohorts. Transl Res. 2022;245:117-129.

*  Chang ML, Cheng JS, Chuang YH, Pao LH, Wu TS, Chen SC, Chang MY, Chien RN. Evolution of Cryoglobulinemia in Direct-Acting Antiviral-Treated Asian Hepatitis C Patients With Sustained Virological Responses: A 4-Year Prospective Cohort Study. Front Immunol. 2022;13:823160.

* Tsai CC, Chen YL, Lu CS, Cheng JS, Weng YH, Lin SH, Wu YM, Wang JJ. Diffusion Tensor Imaging for the differential diagnosis of Parkinsonism by machine learning. Biomed J. 2022:S2319-4170(22)00091-9.

*  Souza CK, Anderson TK, Chang J, Venkatesh D, Lewis NS, Pekosz A, Shaw-Saliba K, Rothman RE, Chen KF, Vincent AL. Antigenic Distance between North American Swine and Human Seasonal H3N2 Influenza A Viruses as an Indication of Zoonotic Risk to Humans. J Virol. 2022 Jan 26;96(2):e0137421.

*  Liu KT, Gong YN, Huang CG, Huang PN, Yu KY, Lee HC, Lee SC, Chiang HJ, Kung YA, Lin YT, Hsiao MJ, Huang PW, Huang SY, Wu HT, Wu CC, Kuo RL, Chen KF, Hung CT, Oguntuyo KY, Stevens CS, Kowdle S, Chiu HP, Lee B, Chen GW, Shih SR. Quantifying Neutralizing Antibodies in Patients with COVID-19 by a Two-Variable Generalized Additive Model. mSphere. 2022 Feb 23;7(1):e0088321.

*  Zapf AJ, Hardick J, McBryde B, Sauer LM, Fenstermacher KZJ, Ricketts EP, Lin YC, Chen KF*, Hsieh YH, Dugas A, Shaw-Saliba K, Pekosz A*, Gaydos CA, Rothman RE; Emergency Department National Network Influenza Investigators. Impact of coinfection status and comorbidity on disease severity in adult emergency department patients with influenza B. Influenza Other Respir Viruses. 2022 Mar;16(2):236-246.

*  Chao HY, Wu CC, Singh A, Shedd A, Wolfshohl J, Chou EH, Huang YC, Chen KF*. Using Machine Learning to Develop and Validate an In-Hospital Mortality Prediction Model for Patients with Suspected Sepsis. Biomedicines. 2022 Mar 29;10(4):802.

*  Su PY, Wei YC, Luo H, Liu CH, Huang WY, Chen KF, Lin CP, Wei HY, Lee TH. Machine Learning Models for Predicting Influential Factors of Early Outcomes in Acute Ischemic Stroke: Registry-Based Study. JMIR Med Inform. 2022 Mar 25;10(3):e32508.

*  Wei YC, Huang WY, Jian CY, Hsu CH, Hsu CC, Lin CP, Cheng CT, Chen YL, Wei HY, Chen KF*. Semantic segmentation guided detector for segmentation, classification, and lesion mapping of acute ischemic stroke in MRI images. Neuroimage Clin. 2022 May 12;35:103044.

*  Tsai TY, Cheong KM, Su YC, Shih MC, Chau SW, Chen MW, Chen CT, Lee YK, Sun JT, Chen KF, Chen KC, Chou EH. Ultrasound-Guided Femoral Nerve Block in Geriatric Patients with Hip Fracture in the Emergency Department. J Clin Med. 2022 May 14;11(10):2778.

*  Yang TH, Chen KF, Gao SY, Lin CC. Risk factors associated with peri-intubation cardiac arrest in the emergency department. Am J Emerg Med. 2022 Jun 11;58:229-234.